Neugeneron

Our approach is to target molecules and pathways within the brain that have been identified through rigorous scientific research as being key players in the disease process.

Our current research and development efforts are on neuroprotective 3’ substituted indolones and 1, 4-benzoxazine compounds.

Our publications related to the discovery of 3’ substituted indolones and 1, 4- benzoxazine compounds

Chin PC, Liu L, Morrison B, Bottiglieri T, Ratan RR, D'Mello SR. (2004) The c-Raf inhibitor GW5074 provides neuroprotection in vitro and in an animal model of neurodegeneration through a MEK-ERK and Akt-independent mechanism. J. Neurochem. 90, 595-608.
K, Liu L Majdazeh N, Chavez C, Chin PC, Morrison B, Wang L, Park J, Chugh P, ChenH-M, D’Mello SR (2005) Inhibition of neuronal apoptosis by the cyclin dependent kinase inhibitor GW8510: Identification of 3’ substituted indolones as a scaffold for the development of neuroprotective drugs. J. Neurochem. 93, 538 - 548.
Johnson K, Liu L Majdazeh N, Chavez C, Chin PC, Morrison B, Wang L, Park J, Chugh P, ChenH-M, D’Mello SR (2005) Inhibition of neuronal apoptosis by the cyclin dependent kinase inhibitor GW8510: Identification of 3’ substituted indolones as a scaffold for the development of neuroprotective drugs. J. Neurochem. 93, 538 - 548.
Chen H-M, Wang L, D’Mello SR. (2008) Inhibition of ATF-3 expression by B-Raf mediates the neuroprotective action of GW5074. J. Neurochem. 105:1300-1132
Chen HM, Wang L, D'Mello SR. (2008) A chemical compound commonly used to inhibit PKR, {8-(imidazol-4-ylmethylene)-6H-azolidino[5,4-g] benzothiazol-7-one}, protects neurons by inhibiting cyclin-dependent kinase. Eur J Neurosci. 28:2003-2016.
Balderamos M, Ankati H, Akubathini SK, Patel AV, Kamila S, Mukherjee C, Wang L, Biehl ER, D'Mello SR. (2008) Synthesis and Structure-Activity Relationship Studies of 3-Substituted Indolin-2-ones as Effective Neuroprotective Agents. Exp Biol Med 233:1395-1402.
Wang L, Ankati H, Akubathini S, Balderamos M, Storey C, Patel AV, Kretzschmar D, Biehl ER, D’Mello SR. (2010) 1, 4- benzoxazine compounds as novel neuroprotective agents. J. Neurosci. Res. 88: 1970-1984.
Ankanti H, Akubathini SK, D’Mello SR., Biehl ER (2010) Synthesis of 2-Benzylidene and 2-Hetarylmethyl Derivatives of 2H-1,4-Benzoxazin-3-(4H)-ones as Neuroprotective Agents” Synth. Communications 40: 2364–2376

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